全文获取类型
收费全文 | 700771篇 |
免费 | 74238篇 |
国内免费 | 49679篇 |
专业分类
电工技术 | 64668篇 |
技术理论 | 76篇 |
综合类 | 75082篇 |
化学工业 | 88735篇 |
金属工艺 | 27691篇 |
机械仪表 | 45099篇 |
建筑科学 | 71667篇 |
矿业工程 | 33426篇 |
能源动力 | 19827篇 |
轻工业 | 40235篇 |
水利工程 | 24654篇 |
石油天然气 | 26147篇 |
武器工业 | 7316篇 |
无线电 | 64312篇 |
一般工业技术 | 54137篇 |
冶金工业 | 37362篇 |
原子能技术 | 7967篇 |
自动化技术 | 136287篇 |
出版年
2024年 | 1243篇 |
2023年 | 8483篇 |
2022年 | 15440篇 |
2021年 | 20548篇 |
2020年 | 20132篇 |
2019年 | 16760篇 |
2018年 | 15941篇 |
2017年 | 21118篇 |
2016年 | 25029篇 |
2015年 | 28230篇 |
2014年 | 42918篇 |
2013年 | 41719篇 |
2012年 | 50008篇 |
2011年 | 53575篇 |
2010年 | 41229篇 |
2009年 | 42039篇 |
2008年 | 41377篇 |
2007年 | 51414篇 |
2006年 | 48296篇 |
2005年 | 41777篇 |
2004年 | 34625篇 |
2003年 | 30110篇 |
2002年 | 23902篇 |
2001年 | 19345篇 |
2000年 | 15880篇 |
1999年 | 13030篇 |
1998年 | 9911篇 |
1997年 | 8444篇 |
1996年 | 7495篇 |
1995年 | 6428篇 |
1994年 | 5591篇 |
1993年 | 4125篇 |
1992年 | 3494篇 |
1991年 | 2676篇 |
1990年 | 2316篇 |
1989年 | 1966篇 |
1988年 | 1479篇 |
1987年 | 963篇 |
1986年 | 744篇 |
1985年 | 737篇 |
1984年 | 751篇 |
1983年 | 533篇 |
1982年 | 549篇 |
1981年 | 367篇 |
1980年 | 314篇 |
1979年 | 212篇 |
1978年 | 134篇 |
1977年 | 153篇 |
1975年 | 87篇 |
1962年 | 103篇 |
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
61.
Mit Rita Goswami Prayas Singh Pankaj Chamoli Sumit Bhardwaj Kuldeep Kumar Raina Ravi Kumar Shukla 《应用聚合物科学杂志》2021,138(43):51260
ZnO rice like nonarchitects are grafted on the graphene carbon core via a rapid microwave synthesis route. The prepared grafted systems are characterized via XRD, SEM, RAMAN, and XPS to examined the structural and morphological parameters. Zinc oxide grafted graphene sheets (ZnO-G) are further doped in β-phase of polyvinylidene fluoride (PVDF) to prepare the polymer nanocomposites (PNCs) via mixed solvent approach (THF/DMF). β-phase confirmation of PVDF PNCs is done by FTIR studies. It is observed that ZnO-G filler enhances the β-phase content in the PNCs. Non-doped PVDF and PNCs are further studied for rheological behavior under the shear rate of 1–100 s−1. Doping of ZnO-G dopant to the PVDF matrix changes its discontinuous shear thickening (DST) behavior to continues shear thickening behavior (CST). Hydrocluster formation and their interaction with the dopant could be the reason for this striking DST to CST behavioral change. Strain amplitude sweep (10−3% -10%) oscillatory test reveals that the PNCs shows extended linear viscoelastic region with high elastic modulus and lower viscous modulus. Effective shear thickening behavior and strong elastic strength of these PNCs present their candidature for various fields including mechanical and soft body armor applications. 相似文献
62.
Paulina Koodziej-Wojnar Joanna Borkowska Zofia Wicik Anna Domaszewska-Szostek Jacek Poosak Marta Ckaa-Jakimowicz Olga Bujanowska Monika Puzianowska-Kuznicka 《International journal of molecular sciences》2021,22(1)
5-Hydroxymethylcytosine (5hmC) is a functionally active epigenetic modification. We analyzed whether changes in DNA 5-hydroxymethylation are an element of age-related epigenetic drift. We tested primary fibroblast cultures originating from individuals aged 22–35 years and 74–94 years. Global quantities of methylation-related DNA modifications were estimated by the dot blot and colorimetric methods. Regions of the genome differentially hydroxymethylated with age (DHMRs) were identified by hMeDIP-seq and the MEDIPS and DiffBind algorithms. Global levels of DNA modifications were not associated with age. We identified numerous DHMRs that were enriched within introns and intergenic regions and most commonly associated with the H3K4me1 histone mark, promoter-flanking regions, and CCCTC-binding factor (CTCF) binding sites. However, only seven DHMRs were identified by both algorithms and all of their settings. Among them, hypo-hydroxymethylated DHMR in the intron of Rab Escort Protein 1 (CHM) coexisted with increased expression in old cells, while increased 5-hydroxymethylation in the bodies of Arginine and Serine Rich Protein 1 (RSRP1) and Mitochondrial Poly(A) Polymerase (MTPAP) did not change their expression. These age-related differences were not associated with changes in the expression of any of the ten-eleven translocation (TET) enzymes or their activity. In conclusion, the distribution of 5hmC in DNA of in vivo aged human fibroblasts underwent age-associated modifications. The identified DHMRs are, likely, marker changes. 相似文献
63.
64.
Hui Huang Bradi R. Lorenz Paula Horn Zelmanovitz Catherine B. Chan 《International journal of molecular sciences》2021,22(1)
Prediabetes is a high-risk condition for type 2 diabetes (T2D). Pancreatic β-cells adapt to impaired glucose regulation in prediabetes by increasing insulin secretion and β-cell mass expansion. In people with prediabetes, metformin has been shown to prevent prediabetes conversion to diabetes. However, emerging evidence indicates that metformin has negative effects on β-cell function and survival. Our previous study established the Nile rat (NR) as a model for prediabetes, recapitulating characteristics of human β-cell compensation in function and mass expansion. In this study, we investigated the action of metformin on β-cells in vivo and in vitro. A 7-week metformin treatment improved glucose tolerance by reducing hepatic glucose output and enhancing insulin secretion. Although high-dose metformin inhibited β-cell glucose-stimulated insulin secretion in vitro, stimulation of β-cell insulin secretion was preserved in metformin-treated NRs via an indirect mechanism. Moreover, β-cells in NRs receiving metformin exhibited increased endoplasmic reticulum (ER) chaperones and alleviated apoptotic unfold protein response (UPR) without changes in the expression of cell identity genes. Additionally, metformin did not suppress β-cell mass compensation or proliferation. Taken together, despite the conflicting role indicated by in vitro studies, administration of metformin does not exert a negative effect on β-cell function or cell mass and, instead, early metformin treatment may help protect β-cells from exhaustion and decompensation. 相似文献
65.
Parkinson’s disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link between DM and PD has been discussed in the literature in relation to different mechanisms including mitochondrial dysfunction, oxidative stress, and protein aggregation. In this paper, we review the common microRNA (miRNA) biomarkers of both diseases. miRNAs play an important role in cell differentiation, development, the regulation of the cell cycle, and apoptosis. They are also involved in the pathology of many diseases. miRNAs can mediate the insulin pathway and glucose absorption. miRNAs can also regulate PD-related genes. Therefore, exploring the common miRNA biomarkers of both PD and DM can shed a light on how these two diseases are correlated, and targeting miRNAs is a potential therapeutic opportunity for both diseases. 相似文献
66.
Anna Masek Stefan Cichosz Magorzata Piotrowska 《International journal of molecular sciences》2021,22(6)
The study aimed to prepare sustainable and degradable elastic blends of epoxidized natural rubber (ENR) with poly(lactic acid) (PLA) that were reinforced with flax fiber (FF) and montmorillonite (MMT), simultaneously filling the gap in the literature regarding the PLA-containing polymer blends filled with natural additives. The performed study reveals that FF incorporation into ENR/PLA blend may cause a significant improvement in tensile strength from (10 ± 1) MPa for the reference material to (19 ± 2) MPa for the fibers-filled blend. Additionally, it was found that MMT employment in the role of the filler might contribute to ENR/PLA plasticization and considerably promote the blend elongation up to 600%. This proves the successful creation of the unique and eco-friendly PLA-containing polymer blend exhibiting high elasticity. Moreover, thanks to the performed accelerated thermo-oxidative and ultraviolet (UV) aging, it was established that MMT incorporation may delay the degradation of ENR/PLA blends under the abovementioned conditions. Additionally, mold tests revealed that plant-derived fiber addition might highly enhance the ENR/PLA blend’s biodeterioration potential enabling faster and more efficient growth of microorganisms. Therefore, materials presented in this research may become competitive and eco-friendly alternatives to commonly utilized petro-based polymeric products. 相似文献
67.
Shi-yuan XU Chu-ming LIU Ying-chun WAN Guang ZENG Yong-hao GAO Shu-nong JIANG 《中国有色金属学会会刊》2021,31(5):1291-1302
The corrosion behaviour of Mg-6Gd-3Y-1Zn-0.3Ag (wt.%) alloy components with different sizes after cooling was investigated. The alloys in the small components (SC) cooled fast, which were composed of α-Mg matrix and coarse long-period stacking ordered (LPSO) phases. The alloys in the large components (LC) cooled slowly, and there were thin lamellar LPSO phases precipitating inside the grains, except for α-Mg matrix and coarse LPSO phases. The hydrogen evolution test revealed that the corrosion rate of LC sample was higher than that of SC sample. Electrochemical impedance spectroscopy (EIS) test showed that the surface film on LC alloys provided worse protection. The corrosion morphologies indicated that the precipitation of the thin lamellar LPSO phases in LC sample caused severe micro-galvanic corrosion, which accelerated the rupture of the surface film. 相似文献
68.
给水管道在使用过程中很容易受到人为外力、管道材质、地下水、周围空气、土壤等因素的影响而腐蚀,影响了管道的使用质量和寿命,也带来较大的安全隐患。本文主要是从给水管道腐蚀原因出发,并探讨防护措施。 相似文献
69.
Felipe A. Perdomo Siti H. Khalit Claire S. Adjiman Amparo Galindo George Jackson 《American Institute of Chemical Engineers》2021,67(3):e17194
The SAFT-γ Mie group-contribution equation of state is used to represent the fluid-phase behavior of aqueous solutions of a variety of linear, branched, and cyclic amines. New group interactions are developed in order to model the mixtures of interest, including the like and unlike interactions between alkyl primary, secondary, and tertiary amine groups (NH2, NH, N), cyclic secondary and tertiary amine groups (cNH, cN), and cyclic methine-amine groups (cCHNH, cCHN) with water (H2O). The group-interaction parameters are estimated from appropriate experimental thermodynamic data for pure amines and selected mixtures. By taking advantage of the group-contribution nature of the method, one can describe the fluid-phase behavior of mixtures of molecules comprising those groups over broad ranges of temperature, pressure, and composition. A number of aqueous solutions of amines are studied including linear, branched aliphatic, and cyclic amines. Liquid–liquid equilibria (LLE) bounded by lower critical solution temperatures (LCSTs) have been reported experimentally and are reproduced here with the SAFT-γ Mie approach. The main feature of the approach is the ability not only to represent accurately the experimental data employed in the parameter estimation, but also to predict the vapor–liquid, liquid–liquid, and vapor–liquid–liquid equilibria, and LCSTs with the same set of parameters. Pure compound and binary phase diagrams of diverse types of amines and their aqueous solutions are assessed in order to demonstrate the main features of the thermodynamic and fluid-phase behavior. 相似文献
70.
天然气水合物储层泥质细粉砂挡砂介质堵塞规律与微观挡砂机制 总被引:1,自引:0,他引:1
中国南海海域部分天然气水合物储层中地层砂为高泥质含量细粉砂,开采防控砂难度较大。针对高泥质细粉砂挡砂机制问题,使用粒度中值为10.13 μm的泥质细粉砂样品,模拟单向气液携砂流动条件,使用绕丝筛板、金属烧结网、金属纤维、预充填陶粒4类挡砂介质在20~80 μm挡砂精度下进行挡砂模拟实验,采用显微成像系统观察挡砂介质内部及表面砂粒沉积与堵塞动态,分析介质流通性能和挡砂性能变化,总结堵塞规律、微观挡砂机制与形态及其控制因素。研究结果表明,不同类型和精度的挡砂介质对泥质细粉砂的堵塞总体呈现堵塞开始、堵塞加剧和堵塞平衡3个阶段。随着驱替进行,挡砂介质渗透率逐渐降低,幅度会高达90%以上;同时过砂速度减缓,最终过砂率为5%~10%。根据堵塞规律和微观图像分析,提出了粗组分分选桥架、局部砂团适度挡砂、整体砂桥阻挡等挡砂介质对泥质细粉砂的3种微观挡砂机制。以粗组分分选桥架挡砂机制为主的挡砂工况下,挡砂介质堵塞渗透率较高,但过砂率超过15%,挡砂效果较差;以整体砂桥挡砂机制为主时,过砂率在10%以下,挡砂性能较好,但各类挡砂介质的堵塞渗透率不足1 D,流通性能较差。局部砂团适度挡砂机制为主时介质挡砂性能及流通性能介于两者之间。挡砂介质对天然气水合物储层泥质细粉砂的微观挡砂机制和形态受挡砂介质类型、精度、地层砂特征以及流动条件等因素控制,其规律对于水合物泥质细粉砂防控砂优化有指导意义。 相似文献